Which of the following lists correctly identifies examples of SNRIs?

• A. Ibuprofen, Diclofenac, Meloxicam, Celecoxib.
• B. Gabapentin, Pregabalin.
• C. Venlafaxine, duloxetine, desvenlafaxine, levomilnacipran.
• D. Sertraline, Fluoxetine.

Answer: (C)

SNRIs are antidepressants that block the reuptake of both serotonin and norepinephrine, increasing the levels of these two neurotransmitters in the brain to help improve mood and, in some cases, pain symptoms. The examples that fit this class are venlafaxine, duloxetine, desvenlafaxine, and levomilnacipran. The other options don’t fit because they belong to different types of drugs: NSAIDs are pain relievers with anti-inflammatory effects, gabapentin and pregabalin are gabapentinoids used for neuropathic pain and seizures, and sertraline and fluoxetine are SSRIs that primarily increase serotonin reuptake inhibition without the norepinephrine component at typical doses.