Which of the following is a representative SGLT2 inhibitor?

• A. Metformin
• B. Pramlintide
• C. Canagliflozin
• D. Exenatide

Answer: (C)

SGLT2 inhibitors block glucose reabsorption in the kidney’s proximal tubule, increasing urinary glucose excretion and lowering blood glucose. Canagliflozin is a representative drug in this class. Metformin is a biguanide that reduces hepatic glucose production and improves insulin sensitivity, not an SGLT2 inhibitor. Pramlintide is an amylin analogue used to slow gastric emptying and suppress glucagon, not part of the SGLT2 class. Exenatide is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, not an SGLT2 inhibitor.