Which of the following is an example of an NSAID?

• A. Ibuprofen, Diclofenac, Meloxicam, Celecoxib.
• B. Norepinephrine-dopamine reuptake inhibitors.
• C. Gabapentin, Pregabalin.
• D. Venlafaxine, duloxetine.

Answer: (A)

NSAIDs work by blocking COX enzymes to reduce prostaglandin production, which lowers inflammation, pain, and fever. The drugs ibuprofen, diclofenac, meloxicam, and celecoxib all fit this category, though they differ in how selectively they inhibit COX-1 versus COX-2. Ibuprofen and diclofenac are nonselective COX inhibitors, meloxicam is more COX-2 selective, and celecoxib mainly targets COX-2. The other options are not NSAIDs: some are antidepressants that affect norepinephrine and dopamine, some are anticonvulsants used for neuropathic pain, and some are serotonin-norepinephrine reuptake inhibitors. Therefore, the group containing ibuprofen, diclofenac, meloxicam, and celecoxib is the correct example of an NSAID.