Which of the following is an example of NSAIDs?

• A. Norepinephrine-dopamine reuptake inhibitors.
• B. Ibuprofen, Diclofenac, Meloxicam, Celecoxib.
• C. Gabapentin, Pregabalin.
• D. Venlafaxine, duloxetine.

Answer: (B)

NSAIDs are drugs that relieve inflammation and pain by inhibiting the cyclooxygenase enzymes (COX-1 and COX-2), which reduces production of prostaglandins involved in inflammation and pain. Ibuprofen, diclofenac, meloxicam, and celecoxib are all NSAIDs, illustrating different COX inhibition profiles—ibuprofen and diclofenac inhibit both COX-1 and COX-2, while meloxicam is more COX-2 selective and celecoxib is COX-2 selective. The other options are not NSAIDs; they are antidepressants or anticonvulsants that affect neurotransmitter systems rather than cyclooxygenase enzymes.