Which of the following is NOT a first-generation antipsychotic?

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Multiple Choice

Which of the following is NOT a first-generation antipsychotic?

Explanation:
Understanding the distinction between typical (first-generation) and atypical (second-generation) antipsychotics helps here. First-generation antipsychotics mainly block dopamine D2 receptors and are effective for positive symptoms but carry a higher risk of extrapyramidal symptoms and prolactin elevation; examples include haloperidol, chlorpromazine, and perphenazine. Risperidone is an atypical antipsychotic, targeting both D2 and serotonin 5-HT2A receptors, which provides antipsychotic effects with a lower risk of EPS at typical doses (though EPS and prolactin elevation can still occur, especially at higher doses) and adds metabolic considerations. Because of this broader receptor profile, risperidone is not categorized as a first-generation antipsychotic.

Understanding the distinction between typical (first-generation) and atypical (second-generation) antipsychotics helps here. First-generation antipsychotics mainly block dopamine D2 receptors and are effective for positive symptoms but carry a higher risk of extrapyramidal symptoms and prolactin elevation; examples include haloperidol, chlorpromazine, and perphenazine. Risperidone is an atypical antipsychotic, targeting both D2 and serotonin 5-HT2A receptors, which provides antipsychotic effects with a lower risk of EPS at typical doses (though EPS and prolactin elevation can still occur, especially at higher doses) and adds metabolic considerations. Because of this broader receptor profile, risperidone is not categorized as a first-generation antipsychotic.

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