What are examples of fibrates?

• A. Fenofibrate, gemfibrozil, bezafibrate.
• B. Glyceryl trinitrate, isosorbide dinitrate, isosorbide mononitrate.
• C. Digoxin, digitoxin, deslanoside.
• D. Atorvastatin, simvastatin, rosuvastatin.

Answer: (A)

Fibrates are lipid-lowering drugs that activate PPAR-α, which increases breakdown of fatty acids and boosts lipoprotein lipase activity, leading to lower triglycerides and usually a modest rise in HDL. The classic examples are fenofibrate, gemfibrozil, and bezafibrate. They’re especially useful for high triglycerides and low HDL. The other drug groups listed serve different purposes: nitrates are used to treat angina by dilating blood vessels; cardiac glycosides like digoxin and digitoxin are used for certain heart rhythm and heart failure conditions; and the statins (atorvastatin, simvastatin, rosuvastatin) inhibit cholesterol synthesis to lower LDL. Since the question asks for examples of fibrates, fenofibrate, gemfibrozil, and bezafibrate are the correct trio.