Gabapentin and Pregabalin belong to which drug class?

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Multiple Choice

Gabapentin and Pregabalin belong to which drug class?

Explanation:
Gabapentin and pregabalin are anticonvulsants, specifically gabapentinoids. They don’t act by activating GABA receptors, despite their name. Instead, they bind to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces calcium influx and lowers the release of excitatory neurotransmitters like glutamate. This dampens neuronal excitability and helps control seizures and neuropathic pain. They’re also used for other conditions such as certain types of neuropathic pain and, off-label, some anxiety disorders. They are not SNRI drugs (which boost serotonin and norepinephrine reuptake inhibition), NSAIDs (which inhibit COX enzymes to reduce inflammation), or NDRIs (which block norepinephrine and dopamine reuptake).

Gabapentin and pregabalin are anticonvulsants, specifically gabapentinoids. They don’t act by activating GABA receptors, despite their name. Instead, they bind to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces calcium influx and lowers the release of excitatory neurotransmitters like glutamate. This dampens neuronal excitability and helps control seizures and neuropathic pain. They’re also used for other conditions such as certain types of neuropathic pain and, off-label, some anxiety disorders. They are not SNRI drugs (which boost serotonin and norepinephrine reuptake inhibition), NSAIDs (which inhibit COX enzymes to reduce inflammation), or NDRIs (which block norepinephrine and dopamine reuptake).

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