Amylin analogues mimic the hormone amylin and have which effects?

• A. Inhibit glucagon production in liver
• B. Stimulate insulin secretion
• C. Increase gastric emptying
• D. Slow gastric emptying, suppress glucagon, promote satiety

Answer: (D)

Amylin analogues mimic amylin’s actions to help regulate post-meal glucose. They slow the rate at which the stomach empties, so glucose enters the bloodstream more gradually and spikes are blunted. They also suppress glucagon secretion, which reduces hepatic glucose production after meals. Additionally, they promote satiety, helping reduce overall food intake. Together, these three effects improve postprandial glucose control.

The other options don’t fit: stimulating insulin secretion isn’t a function of amylin analogues, and increasing gastric emptying is the opposite of what they do. While suppressing glucagon is part of the effect, the best answer combines all three actions—slow gastric emptying, suppress glucagon, and promote satiety.